Sigma Anti-Tensin 1 antibody produced in rabbit 抗体 SAB4200283-200ul

促销价：

价格登录可见

品牌：

Sigma-Aldrich 美国西格玛

CAS号：

计量单位：

支

货号：

SAB4200283-200ul

生产日期：

有效日期：

是否临期：

非临期产品

库存数量:

1(支)

购买数量：

云南腾善生物科技有限公司

SVIP会员

企业类型：私营企业

注册资金：100万元

注册年份：长期有效

主营：实验室产品

地址：云南省-昆明市

进入店铺

热销商品

Merck Millipore 4ml 超滤管 UFC803096 UFC803024 UFC803008

价格登录可见

巴罗克离心管架，PP材质, 50孔，放置15ml离心管 90-1550

价格登录可见

ZETA Life胎牛血清 Z7186FBS-500

价格登录可见

二甲基亚砜

价格登录可见

产品详情

本公司承诺所有上传的商品没有国家限制经营或者需要特殊经营资质的商品，包括但不限于危化品、易制毒品、易制爆品、医疗器械、烟草、药品、毒品和其他违禁品。

属性

生物来源

rabbit

偶联物

unconjugated

抗体形式

affinity isolated antibody

antibody product type

primary antibodies

克隆

polyclonal

形式

buffered aqueous solution

分子量

antigen 225 kDa (rat)
antigen ~150 kDa (human)

species reactivity

rat, human, chicken

增强验证

recombinant expression
Learn more about Antibody Enhanced Validation

浓度

~1.0 mg/mL

technique(s)

immunohistochemistry: 10-20 μg/mL using formalin-fixed, paraffin-embedded rat heart.
indirect immunofluorescence: 3-6 μg/mL using chicken embryo fibroblast cells.
western blot: 1-2 μg/mL using lysates of HEK-293T cells overexpressing human tensin 1

UniProt登记号

Q9HBL0

运输

dry ice

储存温度

−20°C

target post-translational modification

unmodified

Gene Information

human ... TNS1(7145)
mouse ... Tns1(21961)
rat ... Tns1(301509)

说明

一般描述

Tensin 1 (TNS1) is encoded by the gene mapped to human chromosome 2q35. The encoded protein is localized to focal adhesions and is mainly expressed in renal tubular epithelial cells (TECs).

免疫原

synthetic peptide corresponding to a sequence located in the internal region of human tensin1, conjugated to KLH. The corresponding sequence is identical in rat and mouse tensin1.

应用

Anti-Tensin 1 antibody may be used in immunofluorescence and immunohistochemistry.

Anti-Tensin 1 antibody produced in rabbit has been used in immunostaining and immunoblotting.[1][2]

生化/生理作用

Tensin 1 (TNS1) contributes to transforming growth factor (TGF)-β-induced myofibroblast differentiation and extracellular fibronectin and collagen matrix formation. Disruption in the gene and associated signaling might hinder tissue fibrosis. The encoded protein anchors to stress fibers by interacting with cytoplasmic tails of integrins and increases metastatic abilities of cancer cells. Tensin plays a vital role in activation of the c-Jun N-terminal kinases (JNK) and p38 pathways.

Tensin 1 associates with actin, integrin, FAK, p130Cas, DLC-1 and protein phosphatase PP1 which affects cell polarization, migration and invasion. Tensin 1 undergoes extensive Ser/Thr and Tyr phosphorylation induced by extracellular matrix (ECM), various growth factors and oncogenes. In addition, tensin 1 is cleaved by calpain II, a focal adhesion protease, suggesting that tensin 1 plays important roles in organizing the actin cytoskeleton and mediating signal transduction.

外形

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.